EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01816
This submission belongs to the session a. General Organic Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
Floris P. J. T. Rutjes, Henk Hiemstra, Hans E. Schoemaker, Larissa B. Wolf, Jetze W. van Beijma, Sape S. Kinderman, Synthesis of Enantiomerically Pure Pipecolic Acid Derivatives via Combination of Biocatalysis and Transition Metal Catalysis, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01816
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Synthesis of Enantiomerically Pure Pipecolic Acid Derivatives via Combination of Biocatalysis and Transition Metal Catalysis

Sape S. Kinderman 1
Jetze W. van Beijma 1
Larissa B. Wolf 1
Hans E. Schoemaker 2
Henk Hiemstra 1
Floris P. J. T. Rutjes 1,3
1. Institute of Molecular Chemistry,University of Amsterdam Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
2. DSM Research, Life Science Products P.O. Box 18, 6160 MD Geleen, The Netherlands
3. Department of Organic Chemistry, University of Nijmegen Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Abstract
The combination of biocatalysis and transition metal catalysis provides a powerful and versatile pathway for the synthesis of multifunctional building blocks. In this approach, the biocatalyst is used to generate enantiomerically pure starting materials, while transition metals are used in a catalytic fashion for further synthetic elaboration.
Keywords
n/a
Facile and stereoselective synthesis of non-racemic trifluoroalanine
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