Organic menthol crystals: An overview of innovation based on relevant patents

Organic menthol crystals, derived from mint essential oils, are natural, waxy, clear, or white crystalline substances that are solid at room temperature, melting slightly above. Menthol, a cyclic monoterpene alcohol, is synthesized from natural or synthetic precursors and has a significant demand globally, with various protocols available for its synthesis. It is commonly used in perfumery, cosmetics, and medicinal products for its cooling effect and minty scent. Menthol's safety profile and anticancer properties have been extensively studied, showing promising results in inhibiting different cancer cells through multiple pathways like apoptosis induction, cell cycle arrest, and the disruption of tubulin polymerization. Additionally, menthol's impact on respiratory health and digestive issues, and its potential to exacerbate allergic rhinitis have been explored, highlighting both its beneficial and potentially harmful effects on human health.

In this study, we provide an in-depth overview of innovation based on relevant patents related to menthol crystals and its derivatives and their applications. By analyzing these patents, we aim to present the current state of the art and identify emerging trends in the field of plant-derived menthol.

References:

1. Tomar, R.; Kundra, P.; Sharma, J.; Mohajer, F.; Ziarani, M.G.; Yadav, S. An Overview: Synthesis of Menthol using Heterogeneous Catalysis. Letters in Organic Chemistry 2024, 21, 16-28, doi:10.2174/1570178620666230623114308.
2. Zhao, Y.; Pan, H.; Liu, W.; Liu, E.; Pang, Y.; Gao, H.; He, Q.; Liao, W.; Yao, Y.; Zeng, J.; Guo, J. Menthol: An underestimated anticancer agent. Frontiers in pharmacology 2023, 14, doi:10.3389/fphar.2023.1148790.