EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01828
This submission belongs to the session a. General Organic Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
P. Rüedi, A. Linden, S. Furegati, X-Ray Structures of Bicyclic Organophosphates Illustrating the Anomeric Effect, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01828
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X-Ray Structures of Bicyclic Organophosphates Illustrating the Anomeric Effect

S. Furegati
A. Linden
P. Rüedi
Abstract
The influence of the anomeric effect on bicyclic organophosphates could be shown for the first time by means of X-ray analysis. In the course of our syntheses of bicyclic organophosphates as inhibitors of acetylcholinesterase we have been able to crystallize a series of four isomeric compounds: (±)-7-aza-7-benzyl-3-fluoro-2,4-dioxa-3l5- phosphabicyclo[4.4.0]decan-3-ones (±)-1ax,eq and (±)-2ax,eq, cis- and trans-decaline-type congeners with the Fsubstituent in the axial and equatorial position. The syntheses of the mentioned and of some related compounds as well as their inhibitory effects on acetylcholinesterase are described on a separate Poster A0047
Keywords
n/a
Bicyclic Organophosphorus Fluoridates as Inhibitors of Acetylcholinesterase
Novel Synthesis of a,b-Diketoesters from a,a-Dioxo-type Oximes or Oxime Ethers via Zinc-Induced Deoximation