EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01838
This submission belongs to the session a. General Organic Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
Subramanian Karur, Han-Xun Wei, Guigen Li, Halo Aldol Reaction of a,b-Unsaturated Ketones and Aldehydes Mediated by Titanium Tetrachloride, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01838
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Halo Aldol Reaction of a,b-Unsaturated Ketones and Aldehydes Mediated by Titanium Tetrachloride

Guigen Li 1
Han-Xun Wei 1
Subramanian Karur 1
1. Centre for Molecular Architecture, Central Queensland University, North Rockhampton, 4701, QLD, Australia
Abstract
A three-component halo aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited conducting the reaction at 0˚C in dichloromethane or at room temperature within a shortened period. Seven examples were examined to give good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).
Keywords
n/a
Diels-Alder cycloadditions of 1,3-cyclohexadien-4,5-diones(o-benzoquinones) with norbornadiene. Part I. Synthesis.
Functionalization of Double Bonds via Cationic Sulfenyl-X Additions