EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01883
This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
Lajos Kovács, Zoltán Kele, Zoltán Timár, Györgyi Kovács, Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01883
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Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers

Györgyi Kovács 1
Zoltán Timár 1
Zoltán Kele 1
Lajos Kovács 1
1. Nucleic Acids Laboratory, Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary
Abstract
The optimization of peptide nucleic acid (PNA) oligomer synthesis was carried out using Fmoc/acyl-protected monomers on NovaSyn® hydroxy-Tentagel resin and HATU/DIPEA/lutidine activation. The sequences H-Leu-ttttt- Gly-NH2 (1) and H-Gly-cgg-act-aag-tcc-att-gc-Gly-NH2 (2) were prepared and characterized by electrospray mass spectrometry
Keywords
n/a
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