Events The 4th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry

Published date

11 Sep, 2000

Citation

Andreas L. Marzinzik, Eduard R. Felder, Nitrobenzenesulfonylated Amide Linkers on Solid Support: Useful Starting Materials for Diversity Generation, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01884

Facebook

Twitter

Nitrobenzenesulfonylated Amide Linkers on Solid Support: Useful Starting Materials for Diversity Generation

Eduard R. Felder ¹

Andreas L. Marzinzik ²

1. Pharmacia&Upjohn, Discovery Research Oncology, Via Pasteur 10, I-20014 Nerviano, Italy

2. Novartis Pharma AG - Core Technology Area - CH-4002 Basel, Switzerland

Abstract

The Rink-linker (1a) [1] and analogous linkers like 1b [2] and 1c [3] are commonly used not only in peptide chemistry, but also in combinatorial chemistry, for grafting components with a carboxylic group onto the solid phase. Once assembled, the synthesis products are released into solution as carboxamides by acid treatment.

Keywords

n/a

Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers

Polymer-Supported Reagents as Versatile Tools in Combinatorial Chemistry and Total Synthesis