Events The 4th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry

Published date

11 Sep, 2000

Citation

Guido Galley, Alexander Alanine, Fabienne Fredon, One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01886

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One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation

Fabienne Fredon ¹

Alexander Alanine ¹

Guido Galley ¹

1. F. Hoffmann-La Roche AG, Pharmaceuticals Research, CH-4070 Basel, Switzerland

Abstract

A library of 42 diverse propargylamines was prepared using a parallel solution phase synthesis approach. The compounds resulting from the Mannich reaction of acetylenes, paraformaldehyde and secondary amines in the presence of copper(I)-chloride were purified by Solid Phase Extraction.

Keywords

propargylamines

Mannich reaction

library

Solid Phase Extraction

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