EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01890
This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
Jean Martinez, René Lazaro, Frédéric Lamaty, Christine Gauzy, Bérengère Sauvagnat, Stéphane Varray, Poly(ethylene glycol) Supported Synthesis of Aminoacid Derivatives via Ring Closing Metathesis or Microwave-assisted Alkylation, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01890
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Poly(ethylene glycol) Supported Synthesis of Aminoacid Derivatives via Ring Closing Metathesis or Microwave-assisted Alkylation

Stéphane Varray 1
Bérengère Sauvagnat 1
Christine Gauzy 1
Frédéric Lamaty 1
René Lazaro 1
Jean Martinez 1
1. Laboratoire des Aminoacides, Peptides et Protéines (LAPP), CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
Abstract
Ring closing metathesis has been performed for the first time on a soluble poly(ethylene glycol) supported substrate in the presence of Grubbs' catalyst and provided in good yields 6-, 7- and 8-membered ring aminoacid derivatives. The presence of the polymer required the use of a higher amount of ruthenium complex but the addition of a cofactor such as 1-octene improved the turnover of the catalyst. On the other hand, a Schiff base protected glycine supported on a poly(ethylene glycol) reacted readily with various electrophiles in the presence of an inorganic base under microwave activation.
Keywords
n/a
Hydroxy-(2-chlorophenyl)methyl Polystyrene Resin: Studies on the Immobilization and Cleavage of Acids and Alcohols
Dendrimers as Scavengers for Rapid Purification in Solution-Phase Parallel Synthesis