EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01913
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
J. Carlos Menéndez, Carmen Avendaño, Eva Pascual-Alfonso, Synthesis of the pyrido[2,3,4-kl]acridine ring system common to several cytotoxic marine alkaloids, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01913
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Synthesis of the pyrido[2,3,4-kl]acridine ring system common to several cytotoxic marine alkaloids

Eva Pascual-Alfonso 1
Carmen Avendaño 1
J. Carlos Menéndez 1
1. Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia. Universidad Complutense, 28040 Madrid, Spain.
Abstract
An efficient five-step synthesis of the pyrido[2,3,4-kl]acridin-8-one system is described, using a Suzuki coupling of a 4-iodoquinoline and a oxidative demethylation with cobalt trifluoride as the key steps.
Keywords
n/a
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