Events The 4th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-4-01927

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 4th International Electronic Conference on Synthetic Organic Chemistry

Published date

11 Sep, 2000

Citation

Ramachandra S. Hosmane, Vasanthakumar Rajappan, A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01927

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A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines

Vasanthakumar Rajappan ¹

Ramachandra S. Hosmane ¹

1. Laboratory for Drug Design and Synthesis Department of Chemistry & Biochemistry University of Maryland, Baltimore County 1000 Hilltop Circle, Baltimore, Maryland 21250, USA

Abstract

A model study for a novel approach to the synthesis of 2-carboxyinosines has been described. The synthesis of 9-benzyl-2-carboxyhypoxanthine (I), a model for 2-carboxyinosine, was achieved in 4 steps starting from 1-benzyl-5-nitroimidazole-4-carboxylic acid. Also reported is the synthesis of 9-benzyl-2,2-bis(ethoxycarbonyl)hypoxanthine (II).

Keywords

hypoxanthines

2-substitution

2,2-disubstitution

2-carboxyhypoxanthine

2,2-dicarboxylic acid ester

Synthesis of 1-(2'-Deoxy-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5 H,6H)-dion: a Potentially Beneficial Building Block for Antisense Applications

Efficient Preparation of (2R,4'R,8'R)-a-Tocopherol by Hydroxymethylation