EventsThe 4th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-4-01928
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 4th International Electronic Conference on Synthetic Organic Chemistry
Published date
11 Sep, 2000
Citation
Thomas Netscher, Konrad Brüggermann, Johann Riegl, Efficient Preparation of (2R,4'R,8'R)-a-Tocopherol by Hydroxymethylation, in Proceedings of The 4th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2000, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-4-01928
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Efficient Preparation of (2R,4'R,8'R)-a-Tocopherol by Hydroxymethylation

Johann Riegl 1
Konrad Brüggermann 1
Thomas Netscher 1
1. Vitamin Research and Technology Development F. Hoffmann-La Roche, Ltd, CH-4070 Basel, Switzerland
Abstract
(2R,4'R,8'R)-a-Tocopherol (1), the compound with highest vitamin E activity and, therefore, the biologically most valuable tocopherol, plays an important role in feed, food, and pharma industry. Since an economical total synthesis is not feasible up to now, large-scale production by semi-synthesis starts from natural-source material.1 A mixture of a-, b-, g-, and d-tocopherol (1-4) can be obtained from soybean deodorizer distillates (originally a waste stream of soybean processing) by a combination of various physico-chemical purification steps.
Keywords
n/a
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