Prototype behavioural test of memory in Wistar rats exposed to valproic acid: AME Memoriavers maze

Introduction: AME's Memoriavers maze presents the spirit of different memory-related behavioural tests in the same environment. Memoriavers originate from the Latin memoria, which is a function that allows us to integrate, retain, and retrieve information in order to interact with our environment, while others come from the multiverse, which is a set of infinite metaverses operating side by side. Alterations in memory and neurological development caused by valproic acid have been documented, as has neurotoxicity in rodents.

General objective: To evaluate a prototype behavioural memory test in Wistar rats treated with valproic acid.

Materials and methods: A total of 48 male and female Wistar rats were divided into three groups: (1) the distilled water group, (2) the VPA 200 mg/kg group, and (3) the VPA 400 m/kg group. The products were administered daily by gavage for sixty days. After treatment, the rodents were subjected to behavioural tests in AME's home-made Memoriavers maze. Rats were selected from each batch to be mated with untreated rats. The young mated rats were subjected to the same maze.

Results: Various variables, such as the number of errors, exploration time, distance travelled, and others, were recorded. The results of the rats exposed to VPA and their offspring showed a significant drop in success rate and performance. Anxiety and stress were revealed during testing in VPA-treated rodents.

Conclusion: The AME Memoriavers maze showed a decrease in memory-related performance and behavioural abnormalities in Wistar rats treated with valproic acid at the doses studied.