Events The 8th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-8-01958

This submission belongs to the session a. General Organic Synthesis of the event The 8th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2004

Citation

Lukasz Kraszkiewicz, Maciej Sosnowski, Lech Skulski, Oxidative Iodination of Various Deactivated Arenes with I2 or KI in Concentrated Sulfuric Acid, and with Sodium Periodate Added as the Oxidant, in Proceedings of The 8th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2004, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-8-01958

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Oxidative Iodination of Various Deactivated Arenes with I2 or KI in Concentrated Sulfuric Acid, and with Sodium Periodate Added as the Oxidant

Lukasz Kraszkiewicz ¹

Maciej Sosnowski ¹

Lech Skulski ¹

1. Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, 1 Banacha Street, PL 02-097 Warsaw, Poland

Abstract

A number of more or less deactivated arenes, ArH, were effectively mono- or diiodinated with strongly electrophilic I+ reagents prepared from either diiodine or potassium iodide and with added sodium periodate, and reacted for 30 min at 25 – 30 °C in concd (min. 95%) sulfuric acid. The iodinating I+ solutions thus obtained were always applied in a 10% excess in respect to the reacted arenes, with using either the “direct” method or the “inverse” method of aromatic iodination explained in the text. The yields for the iodinated pure products varied from 17% to 91%.

Keywords

oxidation

diiodine

sodium periodate as oxidant

oxidative iodination

deactivated arenes

iodoarenes

Aromatic Iodination Method with Iodic Acid Used as the Iodinating Reagent

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