Event submissions
Published
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 8th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2004
Citation
Martin Dolezal, Lukas Palek, Zuzana Roslerova, Jiri Kunes, Vladimir Buchta, Katarina Kralova, Substituted Pyrazinecarboxamides: Preparation and Biological Activity, in Proceedings of The 8th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2004, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-8-01972
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Substituted Pyrazinecarboxamides: Preparation and Biological Activity
Martin Dolezal 1
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Lukas Palek 1
Zuzana Roslerova 1
Jiri Kunes 2
Vladimir Buchta 3
Katarina Kralova 4
1. Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
2. Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
3. Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
4. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska Dolina CH-2, 842 15 Bratislava, Slovak Republic
Abstract
Newly synthesised pyrazinamide analogues with carboxamide moiety as a bridging ligands between basic and aromatic areas of molecule were tested for their antifungal and photosynthesis-inhibiting activity. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The highest antifungal effect (MIC
Keywords
substituted amides of pyrazin-2-carboxylic acid
antifungal evaluation
photosynthesis inhibition
spinach chloroplasts
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