Events The 8th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-8-01976

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 8th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2004

Citation

Josef Jampilek, Martin Dolezal, Jiri Kunes, Vladimir Buchta, Quinaldine Derivatives Preparation and Their Antifungal Activity, in Proceedings of The 8th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2004, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-8-01976

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Quinaldine Derivatives Preparation and Their Antifungal Activity

Josef Jampilek ¹

Martin Dolezal ¹

Jiri Kunes ²

Vladimir Buchta ³

1. Department of Pharmaceutical Chemistry and Drug Control, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic

2. Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic

3. Department of Biological and Medical Sciences, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic

Abstract

Quinaldine derivatives were obtained, some of them by means of novel synthetic methods. All the compounds were tested for their antifungal activity. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. Structure-activity relationships among the chemical structure, the physical properties and the biological activity of the evaluated compounds are discussed. Brome derivatives of 2-methylquinolin-8-ol possessed the highest antifungal activity against all evaluated fungal strains.

Keywords

quinaldine derivatives

antifungal evaluation

structure-activity relationships

Synthesis of Sulfapyridine Metabolites

Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity