Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

Corylifolinin, also known as isobavachalcone, is a flavonoid compound derived from the seeds of Psoralea corylifolia L. Its rich array of biological activities has positioned corylifolinin as a versatile therapeutic agent. This compound exhibits significant antioxidant, anti-inflammatory, anti-tumor, anti-bacterial, and anti-viral properties, making it a promising candidate for various medical applications.

Apart from its remarkable biological effects, corylifolinin also shows promise in improving liver function and cardiovascular health and providing neuroprotection. Its therapeutic uses are diverse, encompassing conditions such as hepatitis, cardiovascular disease, tumors, and inflammation. This review aims to provide a comprehensive exploration of corylifolinin, covering its sources, biosynthesis, biotransformation, physicochemical properties, absorption, assimilation, metabolism, and excretion.

Furthermore, the review delves into the molecular mechanisms underlying the diverse bioactivities of corylifolinin, as observed in both cellular and animal models. Insights from clinical trials and human studies are discussed, shedding light on the potential therapeutic applications of corylifolinin in human health.

In addition to its benefits, this review addresses toxicological profiles, safety considerations, and existing products and patents related to corylifolinin. This compilation serves as a valuable reference for the development and clinical use of therapies based on corylifolinin, aiming to enhance understanding and facilitate its application in the medical field.