Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02003

This submission belongs to the session a. General Organic Synthesis of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

M. Yus, D. J. Ramón, I. Pastor, J. Ortiz, E. Lorenzo, F. F. Huerta, A. Gutiérrez, D. Guijarro, A. Guijarro, C. Gómez, F. Foubelo, P. K. Choudhury, A. Bachki, F. Alonso, E. Alonso, J. Almena, Functionalized Organolithium Compounds Through an Arene-Catalyzed Lithiation, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02003

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Functionalized Organolithium Compounds Through an Arene-Catalyzed Lithiation

J. Almena ¹

E. Alonso ¹

F. Alonso ¹

A. Bachki ¹

P. K. Choudhury ¹

F. Foubelo ¹

C. Gómez ¹

A. Guijarro ¹

D. Guijarro ¹

A. Gutiérrez ¹

F. F. Huerta ¹

E. Lorenzo ¹

J. Ortiz ¹

I. Pastor ¹

D. J. Ramón ¹

M. Yus ¹

1. Departamento de Química Orgánica, Universidad de Alicante. E-03080 Alicante, Spain

Abstract

Naphthalene- or DTBB-catalyzed lithiation of chloroimines 1, deprotonated chlorobenzyl alcohols, mercaptanes or amines 4, and 3-phenylthiopropylamine 7 in THF at -78deg.C leads to the formation of the corresponding intermediates 2, 5 and 8, which by reaction with carbonyl compounds as electrophiles afford the expected bifunctionalized compounds 3, 6 and 9, respectively.

Keywords

Fuctionalized organolithiums

arene-catalyzed lithiation

Synthesis of Some Sulfur Bridged Pyrimidines, Pyrazoles and Imidazoles

(S)-6-Isopropyl-5-Phenyl-1,2,3,6-Tetrahydro-2-Pyrazinone: A New Chiral Glycine Equivalent for the Synthesis of (Z)-a,b-Didehydro-a-Amino Acid Derivatives