Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02004

This submission belongs to the session a. General Organic Synthesis of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

Jose M. Sansano, Carmen Najera, Tomas Abellan, (S)-6-Isopropyl-5-Phenyl-1,2,3,6-Tetrahydro-2-Pyrazinone: A New Chiral Glycine Equivalent for the Synthesis of (Z)-a,b-Didehydro-a-Amino Acid Derivatives, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02004

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(S)-6-Isopropyl-5-Phenyl-1,2,3,6-Tetrahydro-2-Pyrazinone: A New Chiral Glycine Equivalent for the Synthesis of (Z)-a,b-Didehydro-a-Amino Acid Derivatives

Tomas Abellan ¹

Carmen Najera ¹

Jose M. Sansano ¹

1. Departamento de Quimica Organica, Universidad de Alicante. E-03080 Alicante, Spain.

Abstract

The preparation of N-Boc-protected (S)-6-isopropyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone from (S)-valine and glycine in seven steps and its reactivity with carbonyl compounds affording stereoselectively (Z)-didehydroamino acids derivatives is reported in this communication.

Keywords

Amino acids-didehydro

phase-transfer catalysis

carbonyl compounds

tetrahydro-2-pyrazinone.

Functionalized Organolithium Compounds Through an Arene-Catalyzed Lithiation

Nucleophilic Additions of 2-Furyllithium to Carbonyl Derivatives of L-Serine. Formal Synthesis of (2R,3R)-b-Hydroxy Aspartic Acid.