Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02012

This submission belongs to the session a. General Organic Synthesis of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

Natalie V. Sivova, Ekaterina A. Kishko, Anatoly D. Shutalev, A New Approach to 5-Functionalized Pyrimidine-2-Thiones, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02012

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A New Approach to 5-Functionalized Pyrimidine-2-Thiones

Anatoly D. Shutalev ¹

Ekaterina A. Kishko ¹

Natalie V. Sivova ¹

1. Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Avenue 86, Moscow 117571, Russia.

Abstract

A new general convenient approach to the synthesis of pyrimidine-2-thiones/ones has been developed. This approach is based on the preparation of a-tosyl and a-azido substituted thioureas and ureas followed by the reaction with sodium enolates of carbonyl compounds.

Keywords

Thioureas

ureas

aldehydes

p-toluenesulfinic acid

hydrazoic acid

amidoalkylation

C-H acids

hexahydropyrimidine-2-thiones/ones

1,2,3,4-tetrahydropyrimidine-2-thiones/ones.

A Straightforward Route to Enantiopure Pyrrolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool

New Synthetic Application of Ureidoalkylation in Heterocyclic Chemistry