EventsThe 13th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-13-00202
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 13th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2009
Citation
Davis E. Yakubu, Philppos Konstanidis, Mark Gray, Anthony O’Shaughnessy, J. Jonathan Harburn, Suresh K. Kottakota, Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge, in Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2009, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-13-00202
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Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge

Davis E. Yakubu 1
Philppos Konstanidis 1
Mark Gray 1
Anthony O’Shaughnessy 1
J. Jonathan Harburn 1
Suresh K. Kottakota 1
1. Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK
Abstract
5-BromoVerongamine has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product. 5-BromoVerongamine has been shown to have moderate bacteriacidal activity against MRSA.
Keywords
marine sponge metabolites
bromotyramine
bromotyrosine
anti-bacterials
Preparation and Properties of New Co-crystals of Ibandronate
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