Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02020

This submission belongs to the session a. General Organic Synthesis of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

José M. Quintela, Aniana Díaz, Susanna Conde, M. Carmen Fernández, Vicente Ojea, María Ruiz, Stereoselective Synthesis of 2-Amino-2-methyl-4-phosphonobutanoic Acid Derivatives (MAP4 Analogues), in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02020

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Stereoselective Synthesis of 2-Amino-2-methyl-4-phosphonobutanoic Acid Derivatives (MAP4 Analogues)

María Ruiz ¹

Vicente Ojea ¹

M. Carmen Fernández ¹

Susanna Conde ¹

Aniana Díaz ¹

José M. Quintela ¹

1. Departamento de Química Fundamental e Industrial. Facultade de Ciencias. Universidade da Coruña Campus A Zapateira s/n, A Coruña 15071. Spain.

Abstract

The metabotopic glutamate receptors (mGluRs) constitute a new family of excitatory amino acid receptors, which modulates the synaptic transmission by coupling to second messengers through G-proteins.[1] To date, mGluRs have been distinguished into three groups, based on sequence homology, signal transduction mechanisms and agents pharmacology. In particular, receptors of group III (mGluR4 and mGluR6-8) are characterized by their selective response to several phosphonic acid derivatives. Thus, they are selectively activated by L-2-amino-4- phosphonobutanoic acid (L-AP4, 1 in scheme 1) and competitively antagonized by the a-methylated derivatives of LAP4 (MAP4, 2) and 4-phosphonophenylglycine (MPPG, 3).[2]

Keywords

n/a

Selective Synthesis of the Precursor Thiones for Planar and Cages Tetrathiafulvalenes

Stereoselective Synthesis of 2-Amino-4-phosphono-4-pentenoic Acid Derivatives (AP4 Analogues)