Discovery of Amaranthin as a Promising Drug Target for Vascular Endothelial Growth Factor (VEGF) Therapy

Background: Angiogenesis plays a major role in the process of tumour genesis through its capacity to acquire sustenance in the form of nutrients and oxygen. Hence, defining as one of the hallmarks of cancer. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis both under normal conditions and in disease state, numerous studies has been shown that targeting VEGF has become the most prominent approach to stop tumour growth. Recently, amaranth has become an area of increasing scientific. This is due to its valuable biological properties, and wide pharmacological activity. Therefore it is of interest to study the molecular docking analysis of VEGF with amaranthin compounds as drug target discovery.

Material and methods: A molecular docking study were conclude using autodock vina briefly the VEGF 3D structure was retrieve from protein data bank under the code of 2PVF, Amaranthin were retrieve from PUBCHEM (CID 6325284) both the protein and ligand were prepare using MGLTools then dock using autodick vina (V. 4.0).

Results: the molecular docking results were vizualizate using pymol software ,our results shown that the binding affinity was - 6.8 kcal/mol. Analysis of the docking results showed that selected compound interact with VEGF protein via H bond interactions.

Conclusion: Natural products provide a promising opportunity to discover new compounds that can utilize as drugs given their chemical structure diversity. Of note Amaranthin shown an interesting drug target for targeting VEGF need further studies.