Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02036

This submission belongs to the session a. General Organic Synthesis of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

Peter Rüedi, Mathias Juch, Synthesis of Optically Active n-Alkyloxycatechols as Inhibitors of Lipoxygenase, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02036

Facebook

Twitter

Synthesis of Optically Active n-Alkyloxycatechols as Inhibitors of Lipoxygenase

Mathias Juch ¹

Peter Rüedi ¹

1. Institute of Organic Chemistry, University of Zurich,Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

Abstract

Antioxidant activitv guided fractionation of extracts of Plectranthus sylvestris (labiatae) yielded the novel alkyloxycatechols 1-3 (M. Juch, P. Rüedi, Helv. Chim. Acta 1997, 80, 436). The optically active natural products and several diastereomers have been synthesized. The open chain compounds are prepared by enantioselsective reduction of the corresponding aldol adduct and chromatographic separation of the diastereomers, the cyclic ones by biomimetic phenol oxidation of 2b.

Keywords

n/a

Nucleophilic Additions to 10-Isobornylsulfinimines

Synthesis and Characterization of Ferrocenomesogens containing a Pendent Ferrocenyl Group.