Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02052

This submission belongs to the session b. Combinatorial Synthesis and Automation of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

John A. Porco, Jr, William S. Newcomb, Alasdair A. MacDonald, Steven W. Shuey, Mark A. Scialdone, Optimization of Urea Formation with Phoxim™ Resin using the Nautilus™ 2400, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02052

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Optimization of Urea Formation with Phoxim™ Resin using the Nautilus™ 2400

Mark A. Scialdone ¹

Steven W. Shuey ¹

Alasdair A. MacDonald ²

William S. Newcomb ²

John A. Porco, Jr ²

1. DuPont Central R&D, Wilmington, DE. USA

2. Argonaut Technologies, San Carlos, CA, USA

Abstract

Phosgenated p-nitrophenyl(polystyrene)ketoxime (Phoxime™) resin (1) has been previously utilized as a latent isocyanate equivalent. The Nautilus™ 2400 automated organic synthesizer was used to determine the optimal temperature for thermolysis of the polymer-bound oxime-carbamate derived from Phoxime resin and subsequent amine addition to give a urea in solution.

Keywords

n/a

Convenient synthesis of 1,2,5-(1,3,4)-oxadiazolyl-1,2,4-oxadiazoles

Trapping of Nucleophiles by Rink Resin