Trapping of Nucleophiles by Rink Resin

Commonly, molecules synthesized on a solid support are attached to the solid phase by a linker entity, often an acid labile linker. A commonly used acid labile linker is the "Rink-linker"1 which provides solid phase attachment via an amide or an ester bond. Upon acid treatment target molecules are released, which all bear a "trace of the linker", such as an acid or primary amide functionality. Here, we describe a method to constitute a much wider variety of molecules by trapping a "Rink-cation" with a number of alcohols, amines or thiols.