Events The 1st International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-1-02054

This submission belongs to the session b. Combinatorial Synthesis and Automation of the event The 1st International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Sep, 1997

Citation

Eduard R. Felder, Pietro Petriella, Peter Schneider, Synthesis of a Photolabile `Safety Catch' Linker of the 3'-Methoxybenzoin Type, in Proceedings of The 1st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 1997, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-1-02054

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Synthesis of a Photolabile `Safety Catch' Linker of the 3'-Methoxybenzoin Type

Eduard R. Felder ¹

Pietro Petriella ¹

Peter Schneider ¹

1. Combinatorial Chemistry - Core Technology Area - Novartis Pharma AG - CH-4002 Basel, Switzerland

Abstract

Solid supports carrying a photolabile linker of the 3'-methoxybenzoin type were prepared by a rapid solid phase synthesis method. Alternatively, the linker was preassembled in solution by a more lengthy procedure and then coupled onto polystyrene via its carboxymethyl handle. `Safety catch' linkers of this type are expected to play an important role for the preparation of combinatorial libraries suitable for a variety of miniaturized screening methods, where `reagentless' release of compounds from the carrier is crucial

Keywords

n/a

Trapping of Nucleophiles by Rink Resin

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