Events The 13th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 13th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2009

Citation

Jean Jacques Vanden Eynde, El- Mouktar Aliouat, Muriel Pottier, Eduardo Dei-Cas, Tien L. Huang, Dimitri Stanicki, Julien Laurent, Bisbenzamidines as antifungal agents. Are both amidines functions required to observe an anti-Pneumocystis carinii activity?, in Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2009, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-13-00208

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Bisbenzamidines as antifungal agents. Are both amidines functions required to observe an anti-Pneumocystis carinii activity?

Jean Jacques Vanden Eynde ¹

El- Mouktar Aliouat ^2,3

Muriel Pottier ²

Eduardo Dei-Cas ^2,3

Tien L. Huang ⁴

Dimitri Stanicki ¹

Julien Laurent ¹

1. University of Mons, Laboratory of Organic Chemistry, Faculty of Sciences, Mons, Belgique

2. University of Lille 2, Laboratory of Parasitology, Faculty of Pharmacy, Lille, France

3. Pasteur Institute of Lille, Laboratory of Parasitism Ecology, Lille, France

4. Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, New Orleans, USA

Abstract

A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl and Nhexyl 4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds with inhibition percentages at 0.1μg/ml of 61(percent) and 56(percent) respectively.

Keywords

Convenient synthesis of some novel amino acid coupled triazoles

SYNTHESIS AND IN VIVO IMAGISTIC SKIN EVALUATION OF A NEW DISAZO DYE DERIVED FROM 4,4'-DIAMINOSTILBENE-2,2'- DISULFONIC ACID