Ethnopharmacological role of plant phytoconstituents (Acteoside) in treatment of Alzheimer’s disease

Background: Alzheimer's disease is a progressive neurological disorder that primarily affects memory and cognitive function, mostly affecting the elderly population. Although there are currently no disease-modifying treatments for such neurological disorders, there are a number of ways to reduce the risk of Alzheimer’s through appropriate diagnosis and by using of natural plant products.

Aim(s): The goal of this research study was to see how the main plant phytoconstituents (Acteoside) overcome Alzheimer’s type dementia in rodents by activating the cholinergic system, anti-oxidants, and the protection of neuronal death in the hippocampus region of the brain.

Methods: Investigating the extraction method initially, followed by an in vitro and in vivo investigation in rodent models, and a phytoconstituents analysis using a variety of analytical techniques. Numerous criteria, including behavioral, biochemical, and histological examination, are examined during rodent modeling, using different groups. Subsequently, a standard group including a marketed formulation was used to assess each group.

Results: The hot continuous percolation (Soxhlet) method is used in the preliminary evaluation to determine the percentage yield, which measures 14.10%. Strong antioxidant properties are also shown by the plant extract in the early stages.

Conclusion: The current study suggested that the plant extract in in vivo experiments to prevent related oxidative stress-mediated problems. Further studies are needed to explore the potential medicinal applications of this plant.