ANTI-CONVULSIVE ACTIVITY OF NL197, A DERIVATIVE FROM 4(3H)QUINAZOLINON ON CHEMICAL INDUCED SEIZURE MICE

Objectives: NL197 is a derivative from 4(3H)- quinazolinon and it has been reported to possess central and peripheral effect as well as learning and memory enhancing effect in vivo test. In this present study, we focus on the anticonvulsant effect of NL197 on pentylentetrazol or strychnine induced- seizure mice. Methods: The anticonvulsive activity of NL197 is investigated in experimental seizure models in mice inducing by chemo-convulsant such as pentylenetetrazole (PTZ) 100 mg/kg, SC or strychnine (STN) 2 mg/kg, SC. The anticonvulsive potent of NL197 is also made comparison with that of diazepam 5 mg/kg, PO. Results: In PTZ induced- seizure model, anticonvulsant activity of NL197 NL was determined at the dose of 50 mg/kg, 73.2 mg/kg, and 100 mg/kg. In strychnine induced- seizure model, NL 197 had anticonvulsant activity at dose of 50mg/kg, 73.2mg/kg. No effect was determined with NL197 at dose of 37mg/kg. The protective potent of NL197 againsts PTZ- or STN induced seizures is equal to that of diazepam 5mg/kg, PO at the dose of 73.2 mg/kg and 50 mg/kg, SC, respectively. Conclusions: These present results provided evidence that NL197 has potential anticonvulsant activity in pentylentetrazol or strychnine induced-seizure model in mice as well as diazepam, a standard antiepileptic drug.