Events The 17th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Giang Vo-Thanh, Audrey Aupoix, Chloée Bournaud, Asymmetric transfer hydrogenation of aromatic ketones using rhodium complexes of chiral N-heterocyclic carbenes derived from (S)-pyroglutamic acid., in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a005

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Asymmetric transfer hydrogenation of aromatic ketones using rhodium complexes of chiral N-heterocyclic carbenes derived from (S)-pyroglutamic acid.

Giang Vo-Thanh ¹

Audrey Aupoix ¹

Chloée Bournaud ¹

1. University Paris-Sud

Abstract

A new and flexible procedure for the preparation of chiral azolium salts derived from (S)-pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal-catalyzed asymmetric transfer hydrogenation of aromatic ketones in iso-propanol. Good enantioselectivities up to 90% ee were observed.

Keywords

Asymmetric transfer hydrogenation

N-heterocyclic carbene

Aromatic ketones

(S)-pyroglutamic acid

Azolium salts

Manuscript

ECSOC-Vothanh-NHC.pdf

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