Biocomposites for Regenerative Medicine Applications

Introduction:
The development of biocomposites for regenerative medicine focuses on combining natural and synthetic components to create materials with enhanced bioactivity and functionality. This project explores biocomposites based on poly(vinyl alcohol) (PVA) and bioactive plant extracts from Centella asiatica (Gotu Kola) and Potentilla erecta (Rhizome of Tormentil). These materials aim to promote tissue regeneration and accelerate wound healing.

Methods:
The chemical composition of Gotu Kola and Rhizome of Tormentil extracts was analyzed using high-performance liquid chromatography (HPLC) and spectroscopic methods to identify active compounds such as asiaticoside and catechins. PVA was used as the primary polymer matrix, modified with plant extracts to enhance bioactivity. The biocomposites were synthesized through a solvent casting method, followed by cross-linking to improve mechanical stability. Characterization included swelling behavior, mechanical strength and antioxidant activity.

Results:
The biocomposites exhibited excellent mechanical properties and controlled swelling behavior, making them suitable for regenerative medicine. The incorporation of Gotu Kola extract significantly improved antioxidant and wound-healing properties, while the Rhizome of Tormentil extract contributed anti-inflammatory and antimicrobial effects. Biocompatibility tests showed that the materials support cell attachment and proliferation, confirming their potential for tissue engineering applications.

Conclusion:
The proposed biocomposites demonstrate a promising approach to regenerative medicine, offering a combination of mechanical robustness, bioactivity, and biocompatibility. Future studies will focus on in vivo evaluations and further optimization of extract concentrations to tailor the biocomposites for specific clinical applications.

Acknowledgments: This research was carried out within the SMART-MAT Functional Materials Scientific Club of the Faculty of Materials Engineering and Physics at Cracow University of Technology and as part of the project entitled " Biocomposites for Regenerative Medicine Applications" financed by the FutureLab organization operating at Cracow University of Technology.