Application of Biohydrogels Containing Adaptogens in Innovative Chronic Wound Therapy

The development of biocomposites for regenerative medicine focuses on combining natural and synthetic components to create materials with enhanced bioactivity and functionality. This project explores biocomposites based on poly(vinyl alcohol) (PVA) and bioactive plant extracts from Centella asiatica (Gotu Kola) and Potentilla erecta (Rhizome of Tormentil). These materials aim to promote tissue regeneration and accelerate wound healing.

The chemical composition of Gotu Kola and Rhizome of Tormentil extracts was analyzed using high-performance liquid chromatography (HPLC) and spectroscopic methods to identify active compounds such as asiaticoside and catechins. PVA was used as the primary polymer matrix, modified with plant extracts to enhance bioactivity. The biocomposites were synthesized through a solvent casting method, followed by cross-linking to improve mechanical stability. Characterization included swelling behavior, mechanical strength, antioxidant activity, and biocompatibility.

The biocomposites exhibited excellent mechanical properties and controlled swelling behavior, making them suitable for regenerative medicine. The incorporation of Gotu Kola extract significantly improved antioxidant and wound-healing properties, while the Rhizome of Tormentil extract contributed anti-inflammatory and antimicrobial effects. Biocompatibility tests showed that the materials support cell attachment and proliferation, confirming their potential for tissue engineering applications.

The project is financed with funds from the state budget granted by the Minister of Science within the framework of the "Student Scientific Clubs Create Innovations" (SKN/SP/601893/2024) "Application of Biohydrogels Containing Adaptogens in Innovative Chronic Wound Therapy". The research work was carried out within the SMART-MAT Functional Materials Science Club (section Smart-Mat) at the Faculty of Materials Engineering and Physics of the Cracow University of Technology.