Events The 17th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Pavel A. Solovyev, Anastasia A. Fesenko, Ekaterina A. Dem'yachenko, Anatoly D. Shutalev, A novel selective synthesis of β-isothiocyanato ketones, in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a017

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A novel selective synthesis of β-isothiocyanato ketones

Pavel A. Solovyev ¹

Anastasia A. Fesenko ¹

Ekaterina A. Dem'yachenko ¹

Anatoly D. Shutalev ¹

1. Department of Organic Chemistry, Moscow State University of Fine Chemical Technologies, Moscow, Russian Federation

Abstract

A new selective two-step synthesis of β-isothiocyanato ketones from α,β-unsaturated ketones has been developed. This synthesis includes preparation of β-azidoketones with subsequent reaction of these with triphenylphosphine and carbon disulﬁde. This approach is especially useful for synthesis of β-unsubstituted β-isothiocyanato ketones, which are impossible to prepare with sufficient purity via commonly used procedures.

Keywords

Azides

Isothiocyanates

Carbonyl Compounds

Phosphorus Compounds

Three-component Reaction

Manuscript

ECSOC-2013-rev.pdf

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