Events The 17th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Christian Burmester, Kodai Shiine, Shuntaro Mataka, Thies Thiemann, From Suzuki-Miyaura cross coupling reactions of 2-bromo- and 4-bromoestranes to fluorinated benzofuranoestranes, in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a028

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From Suzuki-Miyaura cross coupling reactions of 2-bromo- and 4-bromoestranes to fluorinated benzofuranoestranes

Christian Burmester ¹

Kodai Shiine ²

Shuntaro Mataka ¹

Thies Thiemann ²

1. Institute of Materials Chemistry and Engineering, Kyushu University

2. Graduate School of Interdisciplinary Engineering, Kyushu University

Abstract

2-Bromoestrone and 4-bromoestrone and the corresponding estradiol derivatives were converted to 2-fluoroaryl- and 4-fluoroarylestrones and estradiols by Suzuki-Miyaura cross-coupling. The coupling products were subjected to an intramolecular aromatic ipso SN reaction to furnish benzofuranoestrones and estradiols. Suzuki-Miyaura cross-coupling reactions were also carried out with other arylboronic acids, using 2-bromoestrane, 4-bromoestrane and 2,4-diiodoestrane as substrates.

Keywords

Suzuki-Miyaura reaction

estrane

benzofuran

ring annelation

fluoro-substituted steroid

Manuscript

main-text-final.pdf

Poster

Presentation1.pdf

Synthesis of Heterocyclic Carbamates with Potential Activity in Plant Protection

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