Events The 17th International Electronic Conference on Synthetic Organic Chemistry

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This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Azadeh Tadjarodi, Salman Najjari, Synthesis and characterization of 4-pyridinecarboxaldehyde thiosemicarbazone, in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a030

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Synthesis and characterization of 4-pyridinecarboxaldehyde thiosemicarbazone

Azadeh Tadjarodi ¹

Salman Najjari ²

1. Research Laboratory of Inorganic Materials Synthesis, Department of Chemistry, Iran University of Science and Technology, Narmak, Tehran, Iran

2. Iran University of Science and Technology

Abstract

Thiosemicarbazones belong to a large group of thiourea derivatives, which obtained by condensation of thiosemicarbazide with suitable aldehydes or ketones. They have biological activities, such as antitumour, antiviral, anticancer, antifungal, antibacterial and antimalarial. In this work, 4-pyridinecarboxaldehyde thiosemicarbazone was synthesized by the reaction of thiosemicarbazide (TSC) and 4-pyridinecarbaldehyde in 1:1 molar ratio in ethanol under reﬂux at 70–80 °C for 2 h. The progress of the reaction was monitored by TLC. After the completion of the reaction, a yellow compound was formed, which was characterized by Fourier transform infrared (FT-IR), ¹H-, ¹³C- NMR spectroscopy and elemental analysis. Spectroscopic data: IR (KBr, cm^-1): 3425(s), 3267(s), 3159(s), 1598(s), 1108(s), 829(m), 619(m), 522(m). ¹HNMR (DMSO-d₆, ppm) δH: 7.74(s, 2H), 7.97 (s, 1H ), 8.19 (s, 1H ), 8. 36 (s, 1H), 8.56 (s, 2H), 11.67(s, 1H) ¹³CNMR (DMSO-d₆, ppm) δC: 122.72, 141.13, 143.07, 151.57, 181.

Keywords

Thiosemicarbazide

Pyridinecarbaldehyde

Spectroscopy.

Manuscript

_Full paper_-Synthesis and characterization of- Tadjarodi-Najari.pdf

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