Events The 17th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Eric Deniau, Stéphane Lebrun, Enantioselective synthesis of 3-substituted isoindolinones via chiral phase-transfer catalyzed intramolecular aza-Michael reactions, in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a033

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Enantioselective synthesis of 3-substituted isoindolinones via chiral phase-transfer catalyzed intramolecular aza-Michael reactions

Eric Deniau ¹

Stéphane Lebrun ¹

1. LCOP, EA CMF 4478

Abstract

Optically active isoindolinones are synthesized by asymmetric intramolecular aza-Michael reactions using cinchoninium phase-transfer organocatalysts. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine-receptor agonists.

Keywords

organocatalysis

phase-transfer catalysis

aza-Michael

heterocycle

isoindolinone.

Manuscript

ecsoc_17_isoindolinones.pdf

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