Multifunctional Synthesized Flavonoid Complexes for Novel Anticancer Drug Coating Applications

Flavonoid-based compounds have attracted significant attention in cancer research due to their potent anticancer properties, including their antioxidant, anti-inflammatory, and anti-proliferative effects. However, their application is often hindered by challenges such as their poor solubility, low bioavailability, and instability under physiological conditions. The MET-EFFECT project (EU-funded under HORIZON-MSCA-SE-2021) aims to address these limitations and focuses on the development of novel multifunctional flavonoid complexes based on rhenium and iridium, with the aim of these serving as metallodrugs and homogenous catalysts. Additionally, the project will propose personalized drug design delivery systems using new green methodologies for valorization in order to improve the delivery and bioavailability of active constituents with potential anticancer properties. These coatings will be tailored to provide controlled release mechanisms that enhance the bioavailability of the active compounds and ensure their targeted delivery to cancerous tissues. The ability to immobilize these biofunctional molecules within films and coatings holds significant potential in advancing the field of drug delivery, enhancing therapeutic efficacy, and contributing to the development of next-generation anticancer therapies. Therefore, the MET-EFFECT project will offer a cutting-edge approach to overcoming the current barriers in cancer treatment by harnessing the power of novel flavonoid-based complexes incorporated into functionalized coatings, presenting a promising solution for localized drug delivery and improved therapeutic outcomes.