Events The 17th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 17th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2013

Citation

Irina Ledeneva, Vitaly Didenko, Victor V. Dotsenko, Khidmet Shikhaliev, Synthesis and reactions of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides, in Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2013, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-17-a040

Facebook

Twitter

Synthesis and reactions of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides

Irina Ledeneva ¹

Vitaly Didenko ¹

Victor V. Dotsenko ^2,3,4

Khidmet Shikhaliev ¹

1. Voronezh State University, 1 Universitetskaya pl., 394006 Voronezh, Russia

2. Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation

3. ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.

4. North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation

Abstract

Cyanothioacetamide reacts with pyrazole-3(5)-diazonium chlorides under mild conditions to afford pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides. The latter can be oxidized with H2O2 to give either pyrazolo[5,1-c][1,2,4]triazine-3-carboxamides or 1,2,4-thiadiazole derivatives, depending on the reaction conditions. The Hantzsch-type reaction of thioamides 5 with α-bromo ketones leads to 3-(thiazol-2-yl)pyrazolo[5,1-c][1,2,4]triazines.

Keywords

Azo-coupling

Cyanothioacetamide

Hantzsch thiazole synthesis

Heterocyclization

Pyrazole-3(5)-diazonium salts

Pyrazolo[5,1-c][1,2,4]triazines

Oxidation of thioamides

Manuscript

C__Users_Victor_Desktop_11.pdf

Crystal Structure of a G-1 Dendrimer of Aminoisophtalic Acid

Microwave-Assisted Synthesis of Cd (II) Complex of 4-Pyridinecarboxaldehyde Thiosemicarbazone