Events The 1st International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Event submissions

Published

This submission belongs to the session S4. New Small molecules as drug candidates of the event The 1st International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Published date

29 Oct, 2025

Academic Editor

Diego Muñoz-Torrero

Citation

Abhavya Shukla, Md. Haroon Ansari, Digambar Kumar Waiker, Akhilesh Tiwari, N. S. Hari Narayana Moorthy, Chandrabose Karthikeyan, Sushant Kumar Shrivastava, Dual Inhibition of AChE and Amyloid-β Aggregation by 3-Vinyl-Quinoxalin-2(1<em>H</em>)-one Derivatives for Alzheimer's Therapy, in Proceedings of The 1st International Electronic Conference on Medicinal Chemistry and Pharmaceutics, 1 November–30 November 2025, MDPI: Basel, Switzerland

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Dual Inhibition of AChE and Amyloid-β Aggregation by 3-Vinyl-Quinoxalin-2(1H)-one Derivatives for Alzheimer's Therapy

Abhavya Shukla ¹

Md. Haroon Ansari ¹

Digambar Kumar Waiker ²

Sushant Kumar Shrivastava ²

Akhilesh Tiwari ¹

N. S. Hari Narayana Moorthy ¹

Chandrabose Karthikeyan ^1,3

1. Cancept Therapeutics Laboratory, Department of Pharmacy, Indira Gandhi National Tribal University, Lalpur, Amarkantak (MP)-484887, India

2. Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India

3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72210, USA.

Abstract

Keywords

3-vinyl-quinoxalin-2(1H)-one

Alzheimer’s disease (AD)

amyloid beta (Aβ)

human acetylcholinesterase (hAChE)

molecular docking