EventsThe 13th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-13-00256
This submission belongs to the session f. Polymer and Supramolecular Chemistry of the event The 13th International Electronic Conference on Synthetic Organic Chemistry
Published date
05 Nov, 2009
Citation
José Vázquez Tato, Francisco Meijide, Aida Jover, Mercedes Álvarez Alcalde, Álvaro Antelo, Synthesis and characterization of new tail-to-tail dimers of bile acids with different spacers, in Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2009, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-13-00256
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Synthesis and characterization of new tail-to-tail dimers of bile acids with different spacers

José Vázquez Tato 1
Francisco Meijide 1
Aida Jover 1
Mercedes Álvarez Alcalde 1
Álvaro Antelo 1
1. Departamento de Química Física, Facultad de Ciencias, Universidad de Santiago de Compostela, Avda. Alfonso X El Sabio s/n, 27002 Lugo, Spain
Abstract
New dimeric steroid-based surfactants derived from 3α,7α,12α-trihydroxy-5β- cholan-24-amine (steroid residue) and isophthalic acid, 5,5'-biisobenzofuran-1,1',3,3'- carboxylic acid and succinic acid (spacers) were synthesized and structurally characterized by NMR techniques. The first spacer was also employed to synthesize the dimer corresponding to the 3α,12α-dihydroxy-5β-cholan-24-amine residue. In all cases the steroid residues are tail-to-tail linked through amide bonds with the spacers.
Keywords
Study the biological activities of Avena sativa extracts
Theoretical calculations on conformations of bile-acid based dimers. Interactions with ibuprofen