Event submissions
Published
This submission belongs to the session a. General Organic Synthesis of the event The 18th International Electronic Conference on Synthetic Organic Chemistry
Published date
03 Nov, 2014
Citation
Ana Maria Silva Soares, Susana Paula Graça Costa, M. Sameiro Torres Gonçalves, Benzoxazole Derivatives as Phototriggers for the Release of Butyric Acid, in Proceedings of The 18th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2014, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-18-a034
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Benzoxazole Derivatives as Phototriggers for the Release of Butyric Acid
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Ana Maria Silva Soares 1
Susana Paula Graça Costa 1
M. Sameiro Torres Gonçalves 1
1. University of Minho
Abstract
In order to evaluate the application of new benzoxazoles and following the previous work regarding benzoxazoles as photoactive groups and using butyric acid as model, in the preparation of carboxylic acid derivatives, butyric ester conjugates were synthesized by reaction with the chloromethylated heterocyclic precursors. Photocleavage studies of the ester conjugates in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (254, 300, 350 and 419 nm) confirmed the quantitative release of the model acid in short irradiation times. Acknowledgements: We thank the Fundação para a Ciência e Tecnologia (FCT) for financial support to the NMR portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho), FCT and FEDER-COMPETE-QREN-EU for financial support to the Research Centre CQ/UM [PEst-C/QUI/UI0686/2013 (FCOMP-01-0124-FEDER-037302)], and a PhD grant to A.M.S.S. (SFRH/BD/80813/2011).
Keywords
Benzoxazoles
phototriggers
butyric acid
Manuscript
Proceeding_Benzoxazoles.pdf
A Novel Photoresponsive Benzoquinolone: Evaluation of the Release of Model Amino Acids
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