Fe₃O₄@ ZrO₂/SO₄^2- as a Nano Magnetic Solid Acid Catalyst for one Pot Synthesis of Benzylamino Coumarin Derivatives

In this research, a new strategy has been introduced for the synthesis of a series of benzylamino coumarin derivatives. Coumarin and its derivatives are an important class of heterocyclic compounds, which constitute the key core of various natural products. These compounds also exhibit a wide band of biological activities including anti-HIV, antimalarial, insecticides, and antioxidants, antibacterial, antiviral, anticoagulant and anticancer activities. Also these compounds have been used in important clinical applications such as Warfarin, Phenprocoumon, Coumatetralyl, Carbochromen, Bromadialone. Nano magnetic sulfated zirconia (Fe₃O₄@ZrO₂/SO₄^2-) can be used as a magnetic solid acid catalyst for the synthesis of benzylamino coumarin derivatives by the reaction of 4-hydroxycoumarin, cyclic secondary amine and aromatic aldehyde at room temperature in acetonitrile. The catalyst (Fe₃O₄@ZrO₂/SO₄^2-) could be easily separated by the use of an external magnetic field and recycled and reused several times without considerable reduction in its activity.