Preparation of Glibenclamide Nanoparticles

One of the progressive ways for increasing oral bioavailability of drug substances with poor solubility is nanoparticles preparation. Glibenclamide (Biopharmaceutical Classification System class II) was chosen as a model compound with low solubility and high permeability. Nanoparticles were prepared either by the antisolvent precipitation – solvent evaporation method or by the emulsion solvent evaporation method. Sodium dodecyl sulphate and macrogol 6000 were used as stabilizing excipients in aqueous solutions with the mass concentrations of 1, 3 and 5%. Acetone and dichloromethane were used as glibenclamide solvents. Ten samples were characterized by dynamic light scattering. The particles size of seven samples ranged from 4.4 to 27.0 nm.