COMPLEXES OF N, N-DONOR DIHYDRAZONE DERIVATIVE: PERSPECTIVE ON SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTIMICROBIAL ANTIOXIDANT AND ANTI-INFLAMMATORY EVALUATION

Hydrazone complexes are gaining more attention in the design of drugs. This had led to lots of studies on metal-base drugs. Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of dihydrazone derivative were synthesized by conventional reflux method in ethanolic medium and characterized by physicochemical and spectral techniques. The molar conductance values of the complexes in DMF were in the range of 14.5 - 25.2 Ohm–1cm2mol–1, signifying their non-electrolytic nature. Magnetic susceptibility measurement confirmed the paramagnetic behaviour of the complexes, except Zn(II) complex that was proved to be diamagnetic. Electronic spectra showed pie bonding to pie-antibonding and non-bonding to pie-antibonding electronic transitions at 280 – 287 nm (absorbance range of 4.54 – 7.41) and 400 – 414 nm (absorbance of 3.06 – 6.32) respectively attributed to C=N moiety . Infrared spectrum of the ligand showed C=N absorption band at 1603 cm-1 which was shifted to 1592 – 1618 cm-1 in the spectra of the complexes due to coordination through nitrogen atom of azomethine groups. Microanalysis agreed with the proposed formulae of the compounds (1:2 metal to ligand ratio). The mass spectrum of the ligand displayed the molecular ion peak at m/z 381 in a positive mode due to [M + H]+ ion. The TGA/DTGA curve of the ligand revealed two sequential stages of weight loss. In-vitro biological evaluation indicated that, all the complexes exhibited enhanced antibacterial, antifungal, antioxidant and anti-inflammatory activities compared to the free ligand. These findings highlighted the potentials of the compounds as promising antimicrobial, antioxidant and anti-inflammatory candidates.