Event submissions
Published
This submission belongs to the session S6. Viral Pathogenesis and Evolution of the event Viruses 2026 – New Horizons in Virology
Published date
09 Mar, 2026
Academic Editor
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Eric FreedCitation
Santseharay Ramirez Almeida, Carlota Fernandez Antunez, Ulrik Fahnøe, Kuan Wang, Itsaso Ortigosa Elorz, Lotte Scheibelein Mikkelsen, Katrine Top Hartmann, Henrik Elvang Jensen, Kenn Holmbeck, Jens Bukh, Sublethal mutagenesis induced by molnupiravir increases genetic diversity of the SARS-CoV-2 quasispecies, decreases pathogenesis in vivo and does not accelerate the emergence of drug resistance, in Proceedings of Viruses 2026 – New Horizons in Virology, Barcelona, 11 March–13 March 2026, MDPI: Basel, Switzerland
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Sublethal mutagenesis induced by molnupiravir increases genetic diversity of the SARS-CoV-2 quasispecies, decreases pathogenesis in vivo and does not accelerate the emergence of drug resistance
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Carlota Fernandez Antunez 1
Ulrik Fahnøe 1
Kuan Wang 1
Itsaso Ortigosa Elorz 1
Lotte Scheibelein Mikkelsen 1
Katrine Top Hartmann 2
Henrik Elvang Jensen 2
Kenn Holmbeck 1
Jens Bukh 1
Santseharay Ramirez Almeida 1
1. Copenhagen Hepatitis C Program (CO-HEP). Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen. Department of Infectious Diseases, Hvidovre Hospital
2. Department of Veterinary and Animal Sciences, University of Copenhagen
Abstract
Keywords
Molnupiravir
coronavirus
nucleotide analog
evolution
mutagenesis
genetic-diversity
fitness
virulence
resistance
cell-culture
Syrian hamsters