EventsThe 19th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-19-a025
This submission belongs to the session a. General Organic Synthesis of the event The 19th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2015
Citation
Sravanthi Devi Guggilapu, Synthesis of novel (±)-cis-exo-norbornane amino acid containing cyclic hexapeptide: Analogue of Dolastatin 16 , in Proceedings of The 19th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2015, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-19-a025
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Synthesis of novel (±)-cis-exo-norbornane amino acid containing cyclic hexapeptide: Analogue of Dolastatin 16

Sravanthi Devi Guggilapu 1
1. NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, HYDERABAD-500037
Abstract

Novel cyclohexapeptide has been synthesized by replacing the unusual amino acids (dolaphenvaline and dolaphenleuine) of dolastatin 16 with (±)-cis-exo-norbarnane and phenyl alanine amino acids. Novel cyclic hexapeptide alongwith dimers, tetramers composed of alternating L-proline subunits have been synthesized in solution phase and well characterized.

Keywords
Dolastatin 16
exo-norbornane amino acid
peptide synthesis
cyclic hexapeptide.
Manuscript
Manuscript for sciforum.pdf
Poster
sciforum-006262.pdf
sciforum-006262.pdf
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