Event submissions
Published
This submission belongs to the session a. General Organic Synthesis of the event The 19th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2015
Citation
Sunil V Gaikwad, Pradeep D Lokhande, Milind D Nikalje, SYNTHESIS OF 1, 3 – DIKETOKETONES A NOVEL ANTIMICROBIAL AND ANTI FUNGAL AGENTS, in Proceedings of The 19th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2015, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-19-a045
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SYNTHESIS OF 1, 3 – DIKETOKETONES A NOVEL ANTIMICROBIAL AND ANTI FUNGAL AGENTS
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Sunil V Gaikwad 1
Pradeep D Lokhande 1
Milind D Nikalje 1
1. 1Department of Chemistry, Dr. D.Y. Patil Arts, Commerce & Science Women College; Pimpri, Pune-411018
Abstract
Abstract
An improved method for synthesis of 2,4-diacetyl-cyclohexanone derivatives is reported with enhanced yield in presence of DMSO as solvent. In situ, reaction of aromatic and hetero aromatic aldehydes with β-oxo-ketones undergoing Knoevenagel condensation, Michael addition followed by aldol condensation to give the desired product in excellent yield. displayed prominent mild to moderate antimicrobial and antifungal activities. The 2,4-diacetyl-cyclohexanone derivatives thus obtained have been characterized by 1H NMR, 13CNMR, FT-IR, MASS, HRMS and X-ray single Crystallography spectroscopic methods.
Keywords
Antimicrobial activity
Heteroaromatic aldehyde
β-keto ketones
DMSO
Knoevenagel /Michael/Aldol reaction.1HNMR
13C NMR
X-ray single crystallography.
Manuscript
Conference Sunil. paper..pdf
Poster
Conference SUNIL_presentation.pdf
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