EventsThe 19th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-19-b002
This submission belongs to the session b. Bioorganic, Medicinal and Natural Products Chemistry of the event The 19th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2015
Citation
Maria João Matos, Fernanda Borges, Lourdes Santana, Eugenio Uriarte, Benedetta Era, Antonella Fais, Francesca Pintus, Amalia Di Petrillo, Rosaria Medda, Martina Caboni, Interest of 3-arylcoumarins as xanthine oxidase inhibitors, in Proceedings of The 19th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2015, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-19-b002
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Interest of 3-arylcoumarins as xanthine oxidase inhibitors

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Maria João Matos 1
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Fernanda Borges 2
Lourdes Santana 1
Eugenio Uriarte 1
Rosaria Medda 3
Francesca Pintus 3
Martina Caboni 3
Benedetta Era 3
Antonella Fais 3
Amalia Di Petrillo 3
1. Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
2. CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
3. Department of Life Science and Environment, University of Cagliari, 09042 Monserrato, Cagliari, Italy
Abstract

In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout.

Keywords
3-Arylcoumarins • Condensation reaction • Cross-coupling reaction • Xanthine oxidase inhibitors • Gout
Manuscript
ECSOC 19 Matos et al..pdf
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