Events The 19th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Bioorganic, Medicinal and Natural Products Chemistry of the event The 19th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Oct, 2015

Citation

Jiri Kos, Katarina Kralova, Matus Pesko, Michal Oravec, Tomas Gonec, Josef Jampilek, Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]naphthalen-2-yl N‑Alkylcarbamates, in Proceedings of The 19th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2015, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-19-b006

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Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]naphthalen-2-yl N‑Alkylcarbamates

Tomas Gonec ¹

Matus Pesko ²

Jiri Kos ¹

Michal Oravec ³

Katarina Kralova ⁴

Josef Jampilek ¹

1. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic

2. Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia

3. Global Change Research Centre AS CR, Belidla 986/4a, 603 00 Brno, Czech Republic

4. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia

Abstract

In this study a series of eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl N‑alkylcarbamates was prepared and characterized. The discussed compounds were prepared by microwave-assisted and conventional synthesis. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was moderate; the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl N-propylcarbamate, and the compounds were found to inhibit PET in photosystem II.

Keywords

N-Alkylcarbamates

Hydroxynaphthalenecarboxamides

PET inhibition

Spinach chloroplasts

Structure-activity relationships

Manuscript

ECSOC-19_MS-006091.pdf

MICROWAVE-ASSISTED EXTRACTION OF BIOACTIVE COMPOUNDS FROM SEEDS OF MILK THISTLE, BLACK CUMIN AND CORIANDER

Preparation of Hydrochlorothiazide Nanoparticles