Reactive methylene compounds as synthons for various bio active molecules

Novel malonamic acid, hydrazide and amide were efficiently synthesized from the condensation of 3-NO₂ aniline with diethyl malonate. Also the synthesis of coumarins, azo coumarins. benzo coumarins, cinnamamide, and α:β-unsaturated acid, were achieved by the reaction of above synthesized compounds in a single step reaction in good to excellent yields. And these eight compounds were tested for their antibacterial activities with two bacteria E. coli and S. aureus. Compounds are showing slightly to moderate antibacterial activities against same bacteria's.